Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 191014-55-8, name is 4-Fluoro-2-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Formula: C8H6FNO
A solution of lithium diisopropylamide (18.20 mL, 36.39 mmol) in THF (25 mL) was stirred at -78 C for =10 minutes. A solution of 4-fluoro-2-methoxybenzonitrile (5.00 g, 33.08 mmol) in THF (15 mL) was added dropwise over 10 minutes and the resulting mixturewas stirred at -78 for 1 h. The reaction mixture was poured over dry ice (excess) and then allowed to warm to room temperature over several hours. After all the dry ice had evaporated the crude product was dissolved in DCM (125 mL) and extracted with saturated aqueous NaHCO3 (2 x 70 mL). The combined aqueous extracts were acidified with conc. HC1 to pH = =2, extracted with DCM (2 x 75 mL). The combined organic layers were dried(Na2SO4) and concentrated at reduced pressure to provide the product as a light yellow solid (4.5 g, 69%). ?H NMR (400MHz, DMSO-d6) oe = 7.97 (dd, J = 6.3, 8.6 Hz, 1H), 7.26 (t, J = 8.8 Hz, 1H), 4.00 (s, 3H).
The synthetic route of 191014-55-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DART NEUROSCIENCE, LLC; BASINGER, Jillian; BOOKSER, Brett; CHEN, Mi; CHUNG, DeMichael; GUPTA, Varsha; HUDSON, Andrew; KAPLAN, Alan; NA, James; RENICK, Joel; SANTORA, Vincent; WO2015/164520; (2015); A1;,
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