Adding a certain compound to certain chemical reactions, such as: 41429-22-5, name is 2-(2-(Difluoromethoxy)phenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41429-22-5, Formula: C9H7F2NO
Synthesis of ethyl (2-difluoromethoxyphenyl)acetate (2-Difluoromethoxyphenyl)acetonitrile (1.45 g) was added dropwise to a solution of chlorotrimethylsilane (2.23 mL) in ethanol (2.0 mL), and the reaction solution was stirred at 50C for five hours. The reaction solution was left to cool to room temperature. Then, potassium carbonate, water and ethyl acetate were added and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 620 mg of the title compound. The property values of the compound are as follows. 1H-NMR (CDCl3) delta (ppm): 1.26 (t, J=7.2Hz, 3H), 3.68 (s, 2H), 4.16 (q, 7.2Hz, 2H), 6.48 (t, J=74.4Hz, 1H), 7.13-7.32 (m, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(Difluoromethoxy)phenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2181992; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts