Electric Literature of 395675-23-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 395675-23-7, name is 2-Chloro-5-fluorophenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-(2-Chloro-5-fluorophenyl)-tetrahydropyran-4-carbonitrile 6.76 g of (2-chloro-5-fluorophenyl)-acetonitrile and 5.7 ml of 2,2-dichlorodiethyl ether are dissolved in 100 ml of dimethylformamide and mixed within 2.5 hours with 3.7 g of sodium hydride (60%) while being cooled with ice. After 3 hours at 0 C. and 16 hours at room temperature, it is mixed with ice water and ethyl acetate, acidified with 1 M hydrochloric acid, and the ethyl acetate phase is washed with water, dried (Na2SO4) and concentrated by evaporation. After chromatography on silica gel, 6.2 g of 4-(2-chloro-5-fluorophenyl)-4-pyranylcarbonitrile, flash point 91-93 C., is obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-fluorophenylacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jaroch, Stefan; Lehmann, Manfred; Schmees, Norbert; Buchmann, Bernd; Rehwinkel, Harmur; Droescher, Peter; Skuballa, Werner; Krolikiewicz, Konrad; Hennekes, Hartwig; Schaecke, Heike; Schottelius, Arndr; US2002/77356; (2002); A1;,
Nitrile – Wikipedia,
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