Reference of 39786-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39786-34-0, name is Ethyl 2-(2-cyanophenoxy)acetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a 2000-mL round-bottom flask was placed a solution of KOtBu (18 g,160.41 mmol) in THF (600 mL) then a THF solution (400 mL) solution of ethyl 2-(2-cyanophenoxy)acetate (20 g,97.46 mmol,as prepared in the previous step) was added dropwise with stirring. After completion of addition,the reaction wasstirred at rt for 2 h,quenched by the addition of water,and extracted with EtOAc (3×200 mL).The organic extracts were combined,washed with brine (2×200 mL),dried over anhydrousNa2SO4,and concentrated under reduced pressure affording 17 g of the title compound as ayellow solid. Mass Spectrum (LCMS,ESI pos): Calcd. for C,,H,2NO3: 206.1 (M+H); Found:206.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(2-cyanophenoxy)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; MUNOZ, Benito; BASTOS, Cecilia, M.; PARKS, Daniel; KOMBO, David; (301 pag.)WO2017/62581; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts