According to the analysis of related databases, 24056-34-6, the application of this compound in the production field has become more and more popular.
In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24056-34-6 as follows. SDS of cas: 24056-34-6
6.4 g (51.1 mmol) of 4-hydroxy-cyclohexanecarbonitrile (121) were dissolved in 120 ml_ of dichloromethane, cooled to 0 0C and 14.9 nriL (13.7 g, 128 mmol) of 2,6-lutidine and 15.4 ml_ (14.9 g, 56.2 mmol) of tert-butyldimethylsilyltrifluoromethanesulfonate were added. The reaction mixture was stirred for 16h at room temperature, then additional 5.0 ml_ of tert-butyldimethylsilyltrifluoromethanesulfonate were added and stirring continued for 1 h. The reaction mixture was diluted with 100 ml_ of dichloromethane and washed with 100 ml_ of water, 80 mL of saturated aqueous sodium bicarbonate solution and 50 mL of brine. The organic phase was dried over magnesium sulphate, filtered, concentrated in vacuo and purified by silica gel chromatography (heptanes:ethyl acetate) to give 9.76 g of the desired product. Rt = 0.95 min (Method 18). Detected mass: 240.1 (M+H+).
According to the analysis of related databases, 24056-34-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI-AVENTIS; WO2009/156100; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts