Brief introduction of

Adding a certain compound to certain chemical reactions, such as: 80517-21-1, name is 4-Fluoro-2-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 80517-21-1, Formula: C7H3FN2O2

EXAMPLE 151Preparation of 2-(2-nitro-4-pyrrolidin-1-ylphenyl)-4,5,6,7-tetrahydro-1 ,3- benzothiazol-7-ol and 2-(7-methoxy-4,5,6,7-tetrahydro-1 ,3-benzothiazol-2-yl)-5-pyrrolidin-1- ylaniline2 Preparation of 2-(2-nitro-4-pyrrolidin-1-ylphenyl)-4,5,6,7-tetrahydro-1 ,3- benzothiazol-7-ol Step A: 2-Nitro-4-pyrrolidin-1-ylbenzonitrileA mixture of 4-fluoro-2-nitrobenzonitrile (1.0 g, 6.02 mmol) and 1.5 mL of pyrrolidine in 25 mL of tetrahydrofuran is stirred at room temperature for 2 hours, then concentrated. The residue is diluted with ethyl acetate, and then washed with saturated sodium chloride (x 3). The organic layer is dried over magnesium sulfate and then filtered through Magnesol. Concentration provides 2-nitro-4-pyrrolidin-1-ylbenzonitrile as a brick red solid (1.05 g). MS: m/z 218.1 (M+ H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-2-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; WYETH; WO2009/120826; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts