Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16213-85-7, name is 2-(2,5-Dimethylphenyl)acetonitrile, A new synthetic method of this compound is introduced below., name: 2-(2,5-Dimethylphenyl)acetonitrile
To a stirred solution of sodium ethoxide (21% in ethanol, 5.34 mL, 68.9 mmol) was added methyl 2-methoxyacetate (5.34 mL, 51.7 mmol) and 2-(2,5-dimethylphenyl)acetonitrile (5.00 g, 34.5 mmol). The resulting reaction mixture was heated to reflux for 14 hours. The reaction was cooled, concentrated, diluted with ethyl acetate (80 mL), and washed with hydrochloric acid (2N). The combined organic layer was dried over sodium sulfate, filtered, and concentrated. Purification by flash column chromatography provided the title molecule as a pale yellow oil (4.00 g, 53%) : ESIMS m/z 218 ([M+H]+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; DOW AGROSCIENCES LLC; GIAMPIETRO, Natalie C.; BAUM, Erich W.; FISCHER, Lindsey G.; GOLDSMITH, Miriam E.; CROUSE, Gary D.; RENGA, James M.; SPARKS, Thomas C.; (234 pag.)WO2016/99929; (2016); A1;,
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