Application of 191014-55-8,Some common heterocyclic compound, 191014-55-8, name is 4-Fluoro-2-methoxybenzonitrile, molecular formula is C8H6FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(S)-4-bromo-2,3-dihydro-1H-inden-1-amine (1.0 g, 4.7 mmol), 4-fluoro-2-methoxybenzonitrile (0.89 g, 5.89 mmol), and N,N-Diisopropylethylamine (0.90 g, 7.1 mmol), were suspended in N-Methyl-2-pyrrolidone (5 mL). The suspension was stirred and heated to 115 C. for 48 h. The reaction was cooled to room temperature, and diluted with ethyl acetate and diethyl ether. The mixture was washed with water and brine, dried over anhydrous sodium sulfate, and concentrated. The product was purified by column chromatography (ethyl acetate/hexanes) to provide (S)-4-((4-bromo-2,3-dihydro-1H-inden-1-yl)amino)-2-methoxybenzonitrile. (S)-4-((4-bromo-2,3-dihydro-1H-inden-1-yl)amino)-5-chloro-2-methoxybenzonitrile:
The synthetic route of 191014-55-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Cho, Aesop; Graupe, Michael; Lad, Lateshkumar Thakorlal; Machicao Tello, Paulo A.; Medley, Jonathan William; Metobo, Samuel E.; Naduthambi, Devan; Phillips, Barton W.; Simonovich, Scott Preston; Wang, Peiyuan; Watkins, William J.; Xu, Jie; Yang, Kin Shing; Ziebenhaus, Christopher Allen; US2020/17471; (2020); A1;,
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