Reference of 55984-93-5,Some common heterocyclic compound, 55984-93-5, name is 2-Methylterephthalonitrile, molecular formula is C9H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 10?mL Pyrex tube equipped with a magnetic stir bar wascharged with 1,4?DCB (25.6 mg, 0.2 mmol), fac?Ir(ppy)3 (2.6mg, 2 molpercent) and DMSO (2 mL). The Pyrex tube was sealed with rubber plug and then deaerated by bubbling Ar for 15 min, then benzaldehyde (30.5 muL, 0.3 mmol) and DIPEA (52.4 muL, 0.3mmol) were added. The reaction system was irradiated with blue LEDs (lambda = 450 ± 10 nm) for 12 h at RT. When the reaction was complete, the aqueous solution was extracted with ethyl acetate (5 mL × 3). The organic extracts were combined, washed with brine and dried over anhydrous sodium sulfate.The solvent was removed under vacuum and the residue was purified by chromatography on silica gel (petroleum ether:ethyl acetate = 3:1) to afford the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methylterephthalonitrile, its application will become more common.
Reference:
Article; Liu, Zan; Nan, Xiaolei; Lei, Tao; Zhou, Chao; Wang, Yang; Liu, Wenqiang; Chen, Bin; Tung, Chenho; Wu, Lizhu; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 39; 3; (2018); p. 487 – 494;,
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