The important role of

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 872091-83-3, name is Methyl 4-chloro-3-(cyanomethyl)benzoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Methyl 4-chloro-3-(cyanomethyl)benzoate

Preparation 7 Methyl 4-chloro-3-(2-methoxy-2-oxoethyl)benzoateIn a 6-litre glass reactor, equipped with a reflux condenser, thermometer, pressure equalizing dropping funnel, and a mechanical stirrer was placed methyl 4-chloro-3- (cyanomethyl)benzoate (461.6 g, 2.2 mol) in methanol (759 ml, 18.7 mol). The mixture was heated to 50 0C. Chloro-trimethyl-silane (1135 ml, 9 mol) was added to this solution over 80 minutes. The mixture was refluxed for 5 hours. There was a heavy evolution of hydrogen chloride gas during this period. The mixture was left at EPO ambient temperature overnight. The solvent was evaporated. After cooling the residue was diluted with dichloromethane (1930 ml) and water (1930 ml). The mixture was stirred for 0.5 hour and the layers were separated. The aqueous phase was extracted with dichloromethane (1000 ml), that was combined with the organic layer, dried over Na2SO4, filtered and concentrated to give oil, which solidified. The residue was used in the next step without purification. (515.8 g, white crystal) Yield: 97.1 %

The synthetic route of 872091-83-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS; WO2006/79857; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts