Synthetic Route of 32446-66-5,Some common heterocyclic compound, 32446-66-5, name is 4,4′-Dicyanobenzophenone, molecular formula is C15H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-[(4-Cyanophenyl)methanehydrazonoyl]benzonitrile (8u). To a mixture of 4-[(4- eyanophenyl)earbonyl]benzonitrile (6u) (0.56 g, 2.4 mmol) and EtOH (30 ml) hydrazine monohydrate (1.8 g, 36 mmol) was added dropwise over 5 mm. The yellow solution wasstirred overnight (about 16 h) at 80C, the mixture was allowed to cool to rt and EtOAe (150 ml) was added. The organic layer was washed with water (50 ml + 2 x 25 ml). The inorganic wash layers were extracted with EtOAe (2 x 25 ml). The organic layers were combined, washed neutral with aq. sat. NaC1 (25 ml), dried over Na2SO4 and concentrated at reduced pressure to afford a slightly red solid 8u (0.51 g, 86%).
The synthetic route of 32446-66-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALLOCYTE PHARMACEUTICALS AG; BREITENSTEIN, Werner; HUERZELER, Marianne; KELLY, Terence; MANCUSO, Riccardo; SCHNEIDER, Gisbert; WEITZ-SCHMIDT, Gabriele; WO2015/189265; (2015); A1;,
Nitrile – Wikipedia,
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