Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H3ClN2O2
2-Amino-4-cyano-1-N-[1-(3,3-diphenylpropyl)-piperidin-4-yl]aniline A mixture of 4-amino-1-(3,3-diphenylpropyl)piperidine di-trifluoroacetate (Method I) (500 mg, 0.96 mmol), 2-chloro,3-nitrobenzonitrile (373 mg, 2.04 mmol) and potassium carbonate (700 mg, 5.05 mmol) in DMSO (4 ml) was heated at 90 C. After 15 h the mixture was poured onto water and extracted with EtOAc (2*30ml). The organics were combined, washed with brine, dried (MgSO4), concentrated and purified by Bond Elut chromatography to give 4-cyano-2-nitro-1-N-[1-(3,3-diphenylpropyl)-piperidin-4-yl]aniline as an oil (300 mg, 0.68 mmol), MS: 442.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Burrows, Jeremy; Cumming, John; Mcinally, Thomas; US2003/119869; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts