Synthetic Route of 906673-45-8,Some common heterocyclic compound, 906673-45-8, name is 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, molecular formula is C14H10BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a three-necked flask, Compound II (20 g) was added, tetrahydrofuran (600 mL), trimethyl borate (14 g) was cooled to -78C, and butyllithium (64 mL, 2.5 M concentration) was added dropwise.The reaction was completed for 30 minutes or more. After the reaction was completed, 1N hydrochloric acid (600 mL) was added to quench the reaction, stirred for 30 minutes or longer, and allowed to stand for stratification.The organic phase was concentrated to dryness under reduced pressure, methanol (200 mL) was added to the resulting oil, concentrated hydrochloric acid (5 mL), and the mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to give about 17 g of the target compound I.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, its application will become more common.
Reference:
Patent; Yaoyuan Pharmaceutical Chemical (Shanghai) Co., Ltd.; Wang Yuan; Liu Chuanjun; Tang Wensheng; He Xungui; (8 pag.)CN107759625; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts