Related Products of 140860-51-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 140860-51-1 as follows.
To a soln. of 2-bromo-4-methoxybenzonitrile (1 g,4.72 mmol )in MeCN (40 rnL) was added Nal (212 g, 14.15 mrnol ) and TMSC1 (1.54 g, 14.15 mmoi). Then the mixture was stirred at 80C overnight, Then the mixture was concentrated in. vacuo and poured into water basified with Na2CO3. The mixture was extracted with EtOAc. The aq. layer was acidified with HC1 and extracted with EtOAc. The organic layer was washed withbrine, dried (Na2SO4). and concentrated in vacuo to give the title compound.
According to the analysis of related databases, 140860-51-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Nitrile – Wikipedia,
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