Electric Literature of 17354-04-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17354-04-0 name is 2-(4,5-Dimethoxy-2-nitrophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 6 5,6-dimethoxy-3H-indol-2-amine A solution of 2-(4,5-dimethoxy-2-nitrophenyl)acetonitrile (0.22 g, 1 mmol) in ethanol (15 ml) was treated with tin chloride (0.50 g, 2.2 mmol) and heated to 70 C. for 72 hours. The reaction mixture was allowed to cool to room temperature, extracted with EtOAc and washed with 1N NaOH and water. The combined organic extracts were dried over MgSO4, filtered and concentrated. HPLC purification provided 5,6-dimethoxy-3H-indol-2-amine (12 mg, 6.2%). 1H NMR (400 MHz, DMSO) delta 11.82 (s, 1H), 9.80 (s, 1H), 9.54 (s, 1H), 7.11 (s, 1H), 6.82 (s, 1H), 4.10 (s, 2H), 3.77 (s, 3H), 3.73 (s, 3H). MS (APCI) m/z 193 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4,5-Dimethoxy-2-nitrophenyl)acetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; AbbVie Inc.; Pliushchev, Marina A.; Chiang, Gary G.; Pappano, William N.; Michaelides, Michael R.; Sweis, Ramzi F.; US2015/274660; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts