906673-45-8, name is 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile
30.2 g (0.1 mol) of 4-[(4-bromo-3-hydroxymethyl)phenoxy)]benzonitrile, 300 ml of dichloromethane, and 30.3 g of triethylamine (0.3 mol) were added to the reaction kettle. The reaction was cooled to 0-10 C, 12.96 g of trimethylchlorosilane was added dropwise, the temperature was controlled to not exceed 10 C, stirred at 25 C for 24 h, quenched with water, extracted with dichloromethane, washed with water and dried over anhydrous magnesium sulfate, filtered, and the solvent was recovered to give an oil (31.8 g) , yield 85%;
The synthetic route of 906673-45-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wuhan Polytechnic University; Zhao Ling; Yang Bo; (8 pag.)CN108659024; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts