Synthetic Route of 133541-45-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 133541-45-4 name is 4-Bromo-2,5-difluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 100 mg (0.46 mmol) 4-bromo-2,5-difluoro-benzonitrile, 146 mg (0.78 mmol) intermediate 111.14, 0.2 ml (1 .42 mmol) DIPEA and DMSO is heated to 100C for 5.5 h. After cooling to RT the reaction mixture is diluted with ACN and water and purified by HPLC giving rise to 1 16 mg 4-bromo-2-[4-(4-cyanophenyl)piperazin-1 -yl]- 5-fluoro-benzonitrile
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2,5-difluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; BLUM, Andreas; PETERS, Stefan; (80 pag.)WO2017/148518; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts