Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 175596-01-7, name is Methyl 4-cyano-2-fluorobenzoate, A new synthetic method of this compound is introduced below., COA of Formula: C9H6FNO2
Step 2: methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate To a solution of methyl 4-cyano-2-fluorobenzoate, obtained in Step 1 (486.8 mg; 2.72 mmol) in abs. EtOH (6 ml_) was added hydroxylamine (0.8 ml 13.6 mmol; 5 eq.) (50% in water) and the mixture was heated at 74C overnight. After cooling, a product precipitated. The precipitate was filtered off and dried under vacuum to afford Intermediate 1 as an off-white solid (267.10 mg; 46%). 1H-NMR (DMSO-d6, 300MHz) delta 10.09 (s, 1 H), 7.92 (t, J = 7.91 Hz, 1 H), 7.69 (dd, J = 1.70 Hz, J = 8.10 Hz, 1 H), 7.64 (dd, J = 1.51 , J = 12.81 , 1 H), 6.05 (s, 2H), 3.90 (s, 3H). HPLC (Method B) Rt 2.99 min (Purity: 100%).
The synthetic route of 175596-01-7 has been constantly updated, and we look forward to future research findings.