Share a compound : C8H6FNO

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 191014-55-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 191014-55-8, name is 4-Fluoro-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Fluoro-2-methoxybenzonitrile

General procedure: Intermediate 31 (1 S.2S)-2-(4-[(R)-4-(4-Cvano-phenoxy)-7-fluoro-indan-1 -yloxyl-phenyl)- cvclopropanecarboxylic acid ethyl ester (1 S,2S)-2-[4-((R)-7-Fluoro-4-hydroxy-indan-1 -yloxy)-phenyl]-cyclopropanecarboxylic acid ethyl ester (Intermediate 5, 146 mg, 0.41 mmol), 4-fluorobenzonitrile (55 mg, 0.45 mmol), and cesium carbonate (145 mg, 0.45 mmol) are suspended in dry dimethylformamide (1 0 mL) and stirred for 3 hours at 100 C followed by room temperature overnight. The mixture is diluted with water and extracted with ethyl acetate. The organic extract is dried over sodium sulfate, filtered and the solvent removed. The residue is purified by flash chromatography (10% ethyl acetate in cyclohexane) to give the title compound (Yield 62 mg). LC (METHOD 5): tR = 1 .54 min ; Mass spectrum (ES+): m/z = 458 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 191014-55-8.