In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4354-73-8, name is 2-Cyclohexylidenemalononitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Cyclohexylidenemalononitrile
General procedure: Triethylamine, 1 mL, was added dropwise with stirring to a solution of 1.5 g (10 mmol) of cyclohexylidenemalononitrile and 10 mmol of substituted phenyl isothiocyanatein 2 mL of DMF. The mixture was stirred for 1 hat 50 C, cooled to room temperature, and diluted with 4 mL of methanol. The precipitate was filtered off, washed with water, and recrystallized from nitromethane. 3-Amino-2-phenyl-1-sulfanylidene-1,2,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (1a) [12].Yield 2.252 g (78%), mp 270-271C. 1H NMR spectrum(DMSO-d6), delta, ppm: 1.75-1.81 m (4H, 6-H, 7-H),2.52-2.58 m (2H, 8-H), 2.67-2.73 m (2H, 5-H), 6.21 br.s (2H, NH2), 7.10-7.15 m (2H, Harom), 7.46-7.52 m (1H, Harom), 7.55-7.63 m (2H, Harom). 13C NMRspectrum (DMSO-d6), deltaC, ppm: 21.2, 22.4, 28.3, 28.5,78.6, 115.6, 126.5, 127.9, 128.8, 130.0, 138.7, 144.4,153.2, 181.9. Found, %: C 68.22; H 5.40; N 14.84;S 11.47. C16H15N3S. Calculated, %: C 68.30; H 5.37;N 14.93; S 11.40.
The synthetic route of 4354-73-8 has been constantly updated, and we look forward to future research findings.