A new synthetic route of 32446-66-5

The chemical industry reduces the impact on the environment during synthesis 4,4′-Dicyanobenzophenone. I believe this compound will play a more active role in future production and life.

Reference of 32446-66-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32446-66-5, name is 4,4′-Dicyanobenzophenone, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 3 4-[alpha-(4-Cyanophenyl)-alpha-hydroxy-5-thiazolylmethyl]-benzonitrile Analogously to Example 1, the title compound is prepared starting from 0.512 ml of diisopropylamine, 2.44 ml of a 1.6M n-butyllithium solution, 530 mg of 2trimethylsilylthiazole and 603 mg of 4,4′-dicyanobenzophenone in THF at -70 and with working up in the same manner. Purification of column chromatography (SiO2, hexane/ethyl acetate 2:2) yields the title compound in pure for. TLC (hexane/ethyl acetate 2:2) Rf =0.2; 1 H-NMR (CDCl3): delta(ppm)=4.39 (s,1H), 7.42 (d,1H), 7.54 and 7.7 (m,8H), 7.88 (d,1H).

The chemical industry reduces the impact on the environment during synthesis 4,4′-Dicyanobenzophenone. I believe this compound will play a more active role in future production and life.