Electric Literature of 76469-88-0, A common heterocyclic compound, 76469-88-0, name is Methyl 4-(cyanomethyl)benzoate, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of methyl iodide (5.35ml) and methyl 4-(cyanomethyl)benzoate (5g) in THF (25ml) was added slowly to a solution of potassium tert-butoxide (8 g) in THF (25ml) at -30 C in an inert atmosphere. The reaction mixture was stirred at RT for about 2 hours. It was then quenched with water (10 ml) and EtOAc was added. The organic and aqueous layers were separated. Organic layer was washed successively with water, brine and dried over sodium sulfate. Organic solvent was concentrated to obtain violet residue which was purified by silica gel column chromatography using 20 % EtOAc – Petroleum ether to obtain off white solid. The off white solid was crystallized in chloroform – petroleum ether to obtain title compound as white solid. *HNMR (CDC13; 300MHz): delta 8.06 (d, 2H), 7.58 (d, 2H), 3.97 (s, 3H), 1.76 (s, 6H); MS (ESI) m/z 204.1 [M+H]+.
The synthetic route of 76469-88-0 has been constantly updated, and we look forward to future research findings.