Application of 56043-01-7, A common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-amino-6-methylbenzonitrile (132.2 mg, 1.0 mmol) was sequentially added to a 100 mL high pressure sealed tube, benzyl alcohol(129.6mg, 1.2mmol, 1.2equiv.), cesium hydroxide monohydrate (167.9mg, 1.0mmol), add an air ball at the sealing mouthAfter stirring at 120 C for 36 h, the product was completely purified by column chromatography by TLC or GC-MS. The isolated yield was 51%.
The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.