Electric Literature of 25808-30-4, These common heterocyclic compound, 25808-30-4, name is 2-(Methylamino)acetonitrile hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A dry one neck 50mL round bottom flask equipped with magnetic stirring, reflux condenser, and nitrogen atmosphere (or drying tube) was charged with the vinamidinium salt (3.30 mmol), methylaminoacetonitrile hydrochloride (0.355 g, 3.33mmol) and triethylamine (0.97 mL, 6.95 mmol).Anhydrous acetonitrile (10 mL) was added and the mixture was allowed to stir at reflux overnight. The flask wascooled to room temperature and the volatiles were removed in vacuo. The remainingsolid was partitioned between water and ethyl acetate. The ethyl acetate layer was dried over sodiumsulfate and concentrated in vacuo togive the crude solid.
Statistics shows that 2-(Methylamino)acetonitrile hydrochloride is playing an increasingly important role. we look forward to future research findings about 25808-30-4.