Adding a certain compound to certain chemical reactions, such as: 2941-29-9, name is Cyclopentanone-2-carbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2941-29-9, Product Details of 2941-29-9
Cyclopentanone-2-carbonitrile (4.00 g, 36.65 mmol), methylhydrazine (2.12 mL, 40.32mmol) and TEA (7.07 mL, 50.89 mmol) in toluene (26.76 mL) were heated to 120 °C for16 hours. The reaction was cooled down to room temperature and the solvent wasevaporated. The residue was taken up into Et20, filtered and dried under vacuo. The filtrate was evaporated and the crude residue was purified via silica gel chromatography(Stationary phase: Irregular SiOH 20-45 jim, 450 g, mobile phase gradient: from 44percentHeptane, 6percent MeOH (+ 10percent NH4OH), 50percent EtOAc to 42percent Heptane, 8percent MeOH (+ 10percentNH4OH), 50percent EtOAc). The pure fractions were collected and evaporated to give 205 mg of intermediate 18b (4percent yield) and 545 mg of intermediate 19b (11percent yield).
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