Adding a certain compound to certain chemical reactions, such as: 154607-01-9, name is 4-Bromo-2-chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154607-01-9, name: 4-Bromo-2-chlorobenzonitrile
A mixture of .4-bromo-2-chlorobenzonitrile (1.082 g, 5 mmol), 5-(4,4,5,5-tetramethyl- 1.3,2«dtoxaborolan-2-yl)mcotinaldehyde (1.165 g, 5.00 mmol), Pd(PPh3J4 (0.144 g. 0.125 mmol), sodium carbonate (2.5 ml, 5.00 mmo.) in 1,4-dioxane (20 mL) was heated to reflux for 6 h. After cooling to room temperature, the solid was filtered and washed by ethyl acetate and water. After drying under vacurnn, yellow powder was collected (1 g). 1H NMR (400 MHz. CDCI3): S 7.63 (dd, J = 1.68, 8 Hz, 1H)1 7.79 (d, J * 1.68 Hz, 1H), 7.83 (d, J » 8 Hz, 1H)1 8.35 (dd, J = 2.24 Hz, 2.04 Hz. 1H)1 9.07 (d, J * 2.36 Hz, 1H), 9.15 (d, J = 1.88 Hz. 1H)1 10.22 (s, 1H).
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