6587-24-2, name is Methyl 2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Methyl 2-cyanobenzoate
From methyl 2-cyanobenzoate (1). To a freshly prepared solution of sodium methoxide obtained by dissolving sodium metal (0.69 g, 30 mmol) in dry MeOH (25 mL), methyl 2-cyanobenzoate (1) (1.61 g, 10 mmol) and malononitrile (1.98 g, 30 mmol) were added with stirring. The obtained yellow-orange solution was refluxed for 8 h till the TLC showed the absence of starting ester 1. Then the resulting suspension was cooled, fine pale yellow precipitate of compound 10a was filtered off, washed with MeOH (10 mL) and dried in air. Pale yellow powder. Yield: 2.00 g (68 %); mp 262-263 C.
The synthetic route of 6587-24-2 has been constantly updated, and we look forward to future research findings.