New learning discoveries about 4-Fluoro-2-(trifluoromethyl)benzonitrile

The synthetic route of 194853-86-6 has been constantly updated, and we look forward to future research findings.

Reference of 194853-86-6, These common heterocyclic compound, 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A DMSO (0.5 mL) solution of 4-fluoro-2- (trifluoromethyl) benzonitrile (0.050 g, 0.26 MMOL, 1 equiv) was treated with cesium carbonate (0.120 g, 0.37 MMOL, 1.4 equiv) and N- (cyclopropylmethyl)-N-propylamine (0.035 g, 0.31 mmol, 1.2 equiv). After 3 h at 90C, the cooled reaction was treated with H2O (1 mL), and extracted with EtOAc (3x 1 mL). Concentration was followed by radial chromatography (SIO2, 1 mm plate, 90: 10; Hex/EtOAc) to afford the title compound as a white solid (0.060 g, 81%) : 1H NMR (CDCI3, 400 MHz) 8 7.51 (d, J = 9.1 Hz, 1 H), 7.00 (d, J = 2.7 Hz, 1 H), 6.84 (dd, J = 9. 0,2. 6 Hz, 1 H), 3.34 (t, J = 7. 7 Hz, 2H), 3.24 (d, J = 6. 4 Hz, 2H), 1.63 (sex, J = 7. 5 HZ, 2H), 1.02 (sept, J = 5. 4 Hz, 1 H), 0.95 (t, J = 7. 4 Hz, 3H), 0.59 (q, J = 5. 7 Hz, 2H), 0.27 (q, J = 5. 0 Hz, 2H).

The synthetic route of 194853-86-6 has been constantly updated, and we look forward to future research findings.