Application of 22364-68-7, These common heterocyclic compound, 22364-68-7, name is 2-(o-Tolyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The general procedure of the CuI catalyst based synthesis method of carbazole derivatives 3 to 8 was as follows: 50 mL two-necked round flasks dried in an oven were charged with nitrosinenamaldehyde (0.5 mmol) or nitrochalcone (0.5 mmol). ,1.0 mmol of benzyl cyanide and 5 mol% CuIdissolved with Cs2CO3(1 equiv)dissolved in 5 mL THFwere added.Each reaction mixture was then refluxed for 6-10 hours until the reaction shown by TLC at open air conditions was complete.The solvent was then removed using a rotary evaporator under reduced pressure to give a residue.The residue was purified by flash column chromatography using silica gel to separate the pure product.
The synthetic route of 22364-68-7 has been constantly updated, and we look forward to future research findings.