Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22433-89-2, name is 4-Bromoisophthalonitrile, A new synthetic method of this compound is introduced below., Product Details of 22433-89-2
Step b. To a stirred solution of tert-butyl 6-(acetamidomethyl)-4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)isoindoline-2-carboxylate (1.000 g, 2.415 mmol) in 1,4-dioxane: water (9: 1, 4.4 ml) were added K2C03 (0.330 g, 2.40 mmol) and 4-bromoisophthalonitrile (CAS Number 22433-89-2; 0.250 g, 1.208 mmol) at rt. The reaction mixture was degassed for 20 min before addition of PdCl2(dppf) (0.080 g, 0.120 mmol). The resulting reaction mixture was heated at 85C for 4 h. The reaction mixture was cooled to rt, poured into water (100 ml) and extracted with EtOAc (3 x 100 ml). The combined organic phase dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography (70% EtOAc in hexane) yielding tert-butyl 6-(acetamidomethyl)-4-(2,4-dicyanophenyl)isoindoline-2-carboxylate (0.120 g, 0.288 mmol). LCMS: Method A, 1.853 min, MS: ES+ 361.58 [M-56].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.