Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H8N2O
Example 9: 2-Methoxy-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]- benzonitrileA suspension of 4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine (180mg, 0.619mmol), 5-amino-2-methoxybenzonitrile(91.7mg, 0.557mmol), in’5′(dibenzylidene-acetone)palladium(0) (28.3mg, 0.030mmol), 4,5- bi5′(diphenylphosphino)-9,9-dimethyl-xanthene (35.8mg, 0.061mmol) and cesium carbonate (403mg, 1.238mmol) in degassed 1,4-dioxane (4mL) was heated at 80C for 2 days. The suspension was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (MgS04) and the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica (ethyl acetate: hexane, 1:1) to afford 2-methoxy-5-[5-(3-morpholin-4-ylphenoxy)- pyrimidin-2-ylamino]-benzonitrile as solid (113mg, 46%).Mass: (ES+) 404 (M+H)+ HPLC: 99%NMR: deltaEta ( 6-DMSO) 3.08 (4H, m), 3.69 (4H, m), 3.88 (3H, s), 6.37 (1H, dd), 6.59 (1H, br s), 6.68 (1H, dd), 7.17 (1H, d), 7.20 (1H, t), 7.86 (1H, dd), 8.12 (1H, d), 8.38 (2H, s) and 9.80 (1H, s).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 214623-57-1.