Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96784-54-2, name is 3-Methyl-4-nitrobenzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C8H6N2O2
To a mixture of 3-methyl-4-nitrobenzonitrile (20g, 12.3 mmol), 3-trifluoromethyl-2,2,2- trifluoroacetophenone (33g, 13.6mmol) and i-Pr2NEt (32g, 24.6mmol) in 40m1 of THF was added TBAF (160g, 61.5 mmol) at room temperature. After the addition, the mixture was refluxed for 24h. Then, the reaction mixture was poured into water and extracted with ethyl acetate three times. The combined organic layers were dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purified by column chromatography on silica gel to give the title compound (36 g, 80% yield). 1H NMR (300Mz, DMSO-d6): delta 3.90 (d, 1H), 4.13 (d, 1H), 7.32 (d, 1H), 7.75-7.79 (m, 3H), 7.88-7.90 (m, 1H), 7.93-8.00 (m, 2H).
The synthetic route of 96784-54-2 has been constantly updated, and we look forward to future research findings.