35704-19-9, name is N-(4-Cyanophenyl)acetamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks
General procedure: A mixture of 1a (34 mg, 0.250 mmol), 2a (149 mg, 0.500 mmol) and TBAT (540 mg, 1.00 mmol) in toluene (3 mL) was stirred at 50 C for 18 h. After this time, the reaction mixture was cooled to ambient temperature and concentrated under reduced pressure. The residue obtained was purified by flash chromatography (silica, heptane to 2:3 ethyl acetate/heptane) to afford 3a (45 mg, 85%) as an off-white solid.
The synthetic route of 35704-19-9 has been constantly updated, and we look forward to future research findings.