In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4553-07-5 as follows. Formula: C11H11NO2
A slurry of sodium hydride (60% dispersion in mineral oil, 811 mg, 20.2 mmol) in dry THF (170 mL) at 0C was added with ethyl 2-cyano-2-phenylacetate (3.2 g, 16.9 mmol). The resulting mixture was stirred for one hour at 0C before adding methyl iodide (2.87 mL, 30.3 mmol) dropwise and slowly warming the mixture to roomtemperature over 16 hours. The mixture was then quenched with saturated aqueous NH4C1 (100 mL) and EtOAc (200 mL). The layers were separated and the aqueous phase was back-extracted with EtOAc (3 x 50 mL). The combined organic phases were dried (MgSO4), filtered and the solvent was removed in vacuo. The residue was purified by silica gel colunm chromatography, eluting with 10% EtOAc in isohexane to give the titlecompound as a colourless oil (2.2 g, 64%).?H NMR (400 MHz, CDC13): oe 7.55-7.5 1 (m, 2 H), 7.44-7.36 (m, 3 H), 4.26-4.22 (m, 2 H), 1.96 (s, 3 H), 1.25 (t, J = 7.2 Hz, 3 H).
According to the analysis of related databases, 4553-07-5, the application of this compound in the production field has become more and more popular.