Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromo-2-methylbenzonitrile
Preparation 13A; 2-methyl-4-? H-pyrrolor2.3-b1Pyridi?-1 -vObenzonitrile; A mixture of 4-bromo-2-methylbenzonitrile (5.45 g, 27.8 mmol), N, N’- dimethyiethyienediamine (0.6 mL, 5.56 mmol), CuI (530 mg, 2.78 mmol), and sodium iodide (7.9 g, 52.8 mmol) in toluene (50 mL) was heated at reflux for 28h. K3PO4 (12.3 g, 58.4 mmol) and 7-azaindole (3.28 g, 27.8 mmol) were added and the mixture was heated at reflux for another 48 h, cooled, filtered, and concentrated. SGC (5% and 10% EtOAc-hexane) of the residue gave the title product as a colorless solid. Yield 2.8 g, 43%. 1H NMR (CDCI3) delta 8.37 (br, 1H), 7.96 (d, 1H, J = 7.5 Hz), 7.86 (s, 1H), 7.80 (d, 1H, J = 8.3 Hz), 7.71 (d, 1H, J = 8.3 Hz), 7.51 (d, 1H1 J = 3.7 Hz), 7.17 (br, 1H)1 6.67 (br, 1H), 2.62 (s, 3H). MS (AP+) m/e 234 (MH+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.