Reference of 64113-84-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64113-84-4, name is 2-Fluoro-5-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 27 N-(2-Cyano-4-methylphenyl)-4-piperidone propylene ketal (29) A solution of 2-fluoro-5-methylbenzonitrile (2.76 g, 20.4 mmol) and 4-piperidone propylene ketal (3.39 g, 21.5 mmol) in DMF (50 mL) was heated in an oil bath (90 C., 20 h). The mixture was diluted with ether and sodium carbonate solution. The aqueous layer was extracted with two additional portions of ether and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. PCTLC (SiO2, 6 mm, 50-0% hexane/CHCl3) afforded the title compound (29). 1H NMR (CDCl3, 400 MHz) consistent with assigned structure. FABLRMS m/e 273 g/mole (M++H, C16H20N2O2=273 g/mole.) HPLC (Vydac; C18; diameter=4.6 mm; length=150 mm; gradient=H2O [0.1% H3PO4]-CH3CN, 95%-5%, 5%-95%, over 16 minutes, 2 ml/min flow rate) RT=9.97 min; focus=215 nm; 97.8% pure.
The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-5-methylbenzonitrile. I believe this compound will play a more active role in future production and life.