Application of 2920-38-9,Some common heterocyclic compound, 2920-38-9, name is [1,1′-Biphenyl]-4-carbonitrile, molecular formula is C13H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the reaction vessel was added 30mol% CuCl, the reaction tube was evacuated, filled with oxygen,In an oxygen atmosphere, 0.2 mmol of p-phenylbenzonitrile, 0.6 mmol of ammonium chloride, 1 ml of acetonitrile and 1 ml of N, N-dimethylformamide were added, the reaction vessel was sealed, and reacted at 25 C,After the reaction is completed, it is washed with water, extracted with ethyl acetate, dried and concentrated by evaporation under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the desired product in a yield of 70%.
The synthetic route of 2920-38-9 has been constantly updated, and we look forward to future research findings.