Related Products of 77326-36-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77326-36-4, name is 2-Amino-6-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-ethylbutan-l-ol (1.02 g, 10.0 mmol) in dry THF (60 mL) was carefully added NaH (60% in mineral oil, 480 mg, 12.0 mmol) in small portions at 0 C under nitrogen. The reaction mixture was stirred at 0 C under nitrogen for 2 hrs. To this solution was added 2- amino-6-fluorobenzonitrile (1.36 g, 10.0 mmol), and the reaction solution was stirred at 0 C – RT for 2 hrs, and then at 65 C overnight under nitrogen. The reaction was cooled down to room temperature then quenched with brine, and extracted with EtOAc (3X). The combined organic layers were washed with brine, dried over Na2S04. Filtered and evaporated under reduced pressure. The residue was purified by chromatography on silica gel (eluent: 20% EtOAc in hexanes) to give the title compound as colorless oil (1.29 g, 59%). 1H NMR (400 MHz, CDC13) delta 0.93 (t, J= 8 Hz, 6H), 1.55-1.43 (m, 4H), 1.73- 1.65 (m, 1H), 3.90 (d, J= 4 Hz, 2H), 4.10 (brs, 2H), 6.25 (d, J = 8 Hz, 1H), 6.34 (d, J = 8 Hz, 1H), 7.20 (t, J = 8 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 2-Amino-6-fluorobenzonitrile. I believe this compound will play a more active role in future production and life.