Synthetic Route of 4640-66-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4640-66-8, name is 4-Chlorophenacylcyanide, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a mixture of appropriate beta-ketonitrile (6a-c, 5.5mmol) and substituted hydrazine or hydrazine hydrochloride(6 mmol) in 20 mL of ethanol was added aqueous 2 M HCl(0.8 mL). The resulting solution was heated at 100 C for 4h. After cooling to room temperature, the mixture was concentrated under reduced pressure. The residue was poured into ice water and basified with aqueous 10% NaOH. The resulting suspension was extracted with diethyl acetate (3 x20 mL). The combined organic layers were dried over Na2SO4 and then concentrated under reduced pressure to afford the title aminopyrazoles, which were purified by crystallization from ethanol.
The chemical industry reduces the impact on the environment during synthesis 4-Chlorophenacylcyanide. I believe this compound will play a more active role in future production and life.