Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Amino-2-fluorobenzonitrile
Step 12: Preparation for 2-Fluoro-5-((5-isopropoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-yl)amino)benzonitrile To a solution of 10-chloro-5-isopropoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline (0.05 g, 0.18 mmol) in isopropanol (3 mL) was added 4-chloro-3-nitroaniline (0.030 g, 0.20 mmol). The solution was stirred at 80 C. for 4 hours. After cooling to ambient temperature, the solution was concentrated to obtain a yellow solid which was purified by column chromatography on silicon gel (dichloromethane:methanol=100:1) to obtain a yellow solid (0.045 g, yield=55%). 1H NMR (DMSO-d6, 400 MHz): delta 10.54 (s, 1H), 8.76 (s, 1 Hz), 8.24-8.23 (m, 1H), 8.04 (t, 1H, J=8.8 Hz), 7.66 (t, 1H, J=8.8 Hz), 7.21 (s, 1H), 4.79 (dd, 1H, J=6 Hz), 4.60 (s, 2H), 4.45 (s, 2H), 1.40 (d, 6H, J=6 Hz); MS: 381(M+H)+.
According to the analysis of related databases, 53312-81-5, the application of this compound in the production field has become more and more popular.