Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-01-3, name is 2-(2,6-Difluorophenyl)acetonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2,6-Difluorophenyl)acetonitrile
Example 13; Preparation of 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid amide. 1-(2,6-Difluorophenyl)cyclopropanecarbonitrile was prepared as described in U.S. Pat. No. 4,859,232 by alkylation of 2,6-difluorophenylacetonitrile with 1,2-dibromoethane in 50% sodium hydroxide in the presence of catalytic amounts of tetrabutylammonium bromide (quantitative yield; GC/MS: m/z 179, RT 8.24 min.; 1H-NMR (DMSO-d6): delta 7.58-7.48 (m, 1H), 7.24-7.16 (m, 2H), 1.84-1.79 (m, 2H), 1.46-1.41 (m, 2H)).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.