886498-08-4, name is 2-Fluoro-5-(trifluoromethoxy)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Fluoro-5-(trifluoromethoxy)benzonitrile
2-fluoro-5-(trifluoromethoxy)benzylamine-d2: To a mixture of2-fluoro-5-(trifluoromethoxy)benzonitrile (374 mg, 1.823 mmol) and sodium borodeuteride (176 mg, 4.19 mmol) in THF (10 mL) at 0 C was added over 45 mm, iodine (463 mg, 1.823 mmol) as a solution in 4 ml THF. The reaction mixture was heatedat reflux for 2 h. After cooling to 0 C, 6 N HC1 (2 ml) was carefully added. This mixture was heated at reflux for 30 mm. After cooling to rt, the mixture was partitioned between EtOAc (40 mL) and 1 N NaOH (40 mL). The organic layer was washed with water (20 mL) and brine (20 mL). After drying over anhydrous sodium sulfate, the organic layer was filtered and concentrated to afford2-fluoro-5-(trifluoromethoxy)benzylamine-d2 (385 mg, 1.823 mmol, 100 % yield)
The synthetic route of 886498-08-4 has been constantly updated, and we look forward to future research findings.