114897-91-5, name is 2-(4-Bromo-2-fluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(4-Bromo-2-fluorophenyl)acetonitrile
(4-Bromo-2-fluoro-phenyl)-acetonitrile (0.255 g, 1.19 mmol), PdCl2(dppf).CH2Cl2 (0.039 g, 0.048 mmol) and N-{2-hydroxy-2-[4(4,4,5,5-tetramethyl-[1,3,2]dioxaboralan-2-yl)phenyl]propyl}-2-propanesulfonamide (0.383 g, 1.0 mmol) are mixed together in dry DMF (30 mL) under N2 at ambient temperature. To this stirred mixture is added 2M Na2CO3 (1.25 mL, 2.5 mmol) and the resulting mixture is heated and stirred at 80 C. for 6 h. The mixture is cooled and poured into EtOAc. The EtOAc is extracted several times with H2O, washed with brine, dried (MgSO4), filtered, and the filtrate evaporated in vacuo. Chromatography on silica gel eluting with EtOAc/hexane gives the intermediate title compound.
The synthetic route of 114897-91-5 has been constantly updated, and we look forward to future research findings.