Month: April 2021

Reference of 2941-29-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2941-29-9, name is Cyclopentanone-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 181 2-(pyridazin-4-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3 -amine1007771 A suspension of 4-hydrazinylpyridazine hydrobromide (0.368 g, 1.93 nimol) in absolute EtOH (5 mL) was treated with 2-oxocyclopentanecarbonitrile (0.191 g, 1.75 mmol) and the mixture was heated at reflux for 22 hours. The mixture was cooled to ambient temperature and was concentrated to an orange solid. The solid was suspended in 1 M NaOH and stirred for 10 minutes. The solid was collected, washed thoroughly with H20 and Et20 and dried in vacuum to furnish title compound as a tan powder (.323 g, 92percent). MS (apci) mz = 202.1 (M+H).

The chemical industry reduces the impact on the environment during synthesis Cyclopentanone-2-carbonitrile. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33279-01-5, name is 3-Oxopentanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Oxopentanenitrile

A solution of 3-oxo-pentanenitrile (1.582 g, 16.49mmol), ethylene glycol (1.026 ml, 84. 59 mmol) and a catalytic amount of p-Toluene sulphonic acid (8 mg) in Toluene (10 ml) is refluxed at 150OC for 2 days using Dean-Stark apparatus. The reaction mixture is diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic phase is dried over MGS04, filtered, and the solvent evaporated to yield (2-ETHYL- [1, 3] dioxolan-2-yl)- acetonitrile. 1H NMR (400MHZ, CDC13) d 4.15 (2H, m), 4.05 (2H, m), 2.65 (2H, s), 1. 80 (2H, q), 0.95 (3H, t)

According to the analysis of related databases, 33279-01-5, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 60710-80-7, name is 3-Amino-4-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60710-80-7, category: nitriles-buliding-blocks

To a solution of 2-chloro-4-phenylquinazoline (9.6 g, 40 mmol) in 2-propanol (130 mL) was added 4-aminobenzoic acid (8.2 g, 60 mmol) and the mixture was stirred at reflux for 4 h. The mixture was cooled to it and the precipitate was collected by filtration and washed with 2-propanol. The product, 4-(4-phenylquinazolin-2-ylamino)benzoic acid, was isolated as a yellow solid (12.9 g, 95 %).[00337] To a stirred mixture of 4-(4-phenylquinazolin-2-ylamino)benzoic acid (1.37 g, 4.02 mmol), 3-amino-4-methylbenzonitrile (529 mg, 4.01 mmol), and Hunig’s base (2.1 mL, 12 mmol) in dimethyl formamide (10 mL) was added HATU (3.04 g, 8.00 mmol). Thestirred mixture was heated to 80 0C overnight, then cooled to rt. The reaction was diluted with ethyl acetate and extracted with water. The organic layer was washed with saturated sodium bicarbonate and concentrated on a rotary evaporator. The residue was sonicated with acetonitrile and filtered to give a light yellow solid, which was again washed with water, acetonitrile, and dried under reduced pressure to give jV-(5-cyano-2-methylphenyl)-4-[(4- phenylquinazolin-2-yl)amino]benzamide (1.18 g, 65%) as a light yellow solid. 1H NMR (400 MHz, DMSOd6): delta 10.36 (s, IH), 9.87 (s, IH), 8.19 (d, 2H), 8.00 (d, 2H), 7.91-7.78 (m, 6H), 7.66-7.62 (m, 4H), 7.51 (d, IH), 7.42 (ddd, IH), 2.36 (s, 3H). MS (EI) for C29H21N5O: 456.1 (MH+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-4-methylbenzonitrile, and friends who are interested can also refer to it.

21524-39-0, name is 2,3-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

To a solution of 51-(pynOlidm-1-ylsulfonyl)spirofl ,3-dioxane-2,3′-indol]-2′(r//)-one (400 mg, 1.2 mmol) in DMF (12 mL) was added 60% NaH (60 mg, 1 5 mmol). After stir?ng for 10 minutes at room temperature, a 3.0 mL aliquot of this solution (0.3 mmol) was added to 2,3-difluorobenzonit?le (83 mg, 0.6 mmol) in DMF (2 mL), The resulting solution was stirred at 60 C for 12 hours. The reepsilonction was diluted with EtOAc, washed with H;O and brme, then dried (MgSO4), filtered, and concentrated. The crude residue was purified by flash chromatography on silica gel (30 1 CH2CI1/ EtOAc) to provide 87 mg (630O) of the title compound as a white solid. 1H NMR (400 MHz, CDCl3) consistent, MS (ES) m,z 458.1 (M-H)

The synthetic route of 21524-39-0 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7048-38-6 as follows. Recommanded Product: (5-Chloro-2-methoxyphenyl)acetonitrile

To a solution of 2-(5-chloro-2-methoxyphenyl)acetonitrile (lOg, 47.84mmol) in ethyl formate (50mL) was added sodium metal (4.4g, 95.6mmol) at room temperature. The resulting reaction mixture was heated at 100°C for 3 hours. After completion of the reaction, it was cooled to room temperature, water (100ml) and dichloromethane (100ml) were added to the reaction mixture and the solution was adjusted to pH-3 with the help of concentrated hydrochloric acid. The layers were separated and the aqueous layer was extracted with dichloromethane (2 x 100ml). The combined organics were washed with saturated aqueous sodium chloride solution (150ml), dried over sodium sulphate, filtered and evaporated in vacuo. The crude product was purified by column chromatography using normal phase silica gel. The desired product eluted at around 0.7 to 0.9percent methanol in dichloromethane. Evaporation of the product fractions gave 9g (yield, 77.94percent) of the desired compound as a white solid. LC-MS: m/z = 208.0(M-H).

According to the analysis of related databases, 7048-38-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 17417-09-3, name is 2-Fluoro-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17417-09-3, Computed Properties of C7H3FN2O2

Under room temperature, into the 3-amino-4-fluorophenol (3 g, 22.42mmol) and 2-fluoro-5-nitrobenzonitrile (4.19 g, 24.66mmol) into DMF (20 mL) solution added K2CO3 (4.89g, 35.4mmol). The solution was stirred at 80C for 8h, and the solution was extracted with ethyl acetate, washed with saturated sodium chloride, drying with anhydrous sodium sulfate, filtering out insoluble matter, filter and concentrate under reduced pressure, the residue obtained was purified by silica gel column chromatography, (eluent: petroleum ether / ethyl acetate = 5:1 -4:1), and the resulting solution was concentrated under reduced pressure, obtained 1.95 g of a light yellow solid, yield is 35%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-5-nitrobenzonitrile, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 53078-71-0, name is 4-Methoxy-3-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53078-71-0, COA of Formula: C9H9NO

REFERENTIAL EXAMPLE 14 To 9.8 g of 4-methoxy-3-methylbenzonitrile, were added 150 ml of carbon tetrachloride, 10 g of NBS, and 0.4 g of BPO. The mixture was heated under reflux for 2.5 hours. The reaction mixture was cooled in ice, filtered from insolubles and concentrated under reduced pressure. The residue was admixed with n-hexane, stirred for 30 minutes, and collected by filtration to yield 9 g of 3-bromomethyl-4-methoxybenzonitrile; m.p. 102-103 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 39581-21-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39581-21-0, name is N-Butyl-2-cyano-acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

The synthetic route of N-Butyl-2-cyano-acetamide has been constantly updated, and we look forward to future research findings.

Synthetic Route of 159847-83-3, The chemical industry reduces the impact on the environment during synthesis 159847-83-3, name is Methyl 2-amino-4-cyanobenzoate, I believe this compound will play a more active role in future production and life.

To a solution of 7-ethoxy-2,3-dihydro-2,2-dimethyl-a-(1-methylethyl)-5-benzofuranmethanol (11.3 g, 42.9 mmol) and methyl 2-amino-4-cyanobenzoate (6.30 g, 35.8 mmol) in toluene (40 ml) and acetic acid (25 ml) was added conc. sulfuric acid (5.92 ml, 111 mmol) under ice-cooling, and the mixture was stirred for 2 hours at 80C. Methanol (18 ml) was added dropwise thereto, and the mixture was stirred for 30 minutes at 65C. After cooling, the reaction mixture was combined with ice water, neutralized with sodium hydrogen carbonate, and extracted three times with ethyl acetate. The combined organic layer was extracted three times with 1 M hydrochloric acid, and the combined aqueous layer was neutralized with sodium hydrogen carbonate, and extracted twice with ethyl acetate. The combined organic layer was washed with a saturated aqueous solution of sodium chloride, dried over sodium sulfate, filtered, and concentrated under reduced pressure. To the residue was added ethyl acetate, and the precipitated crystals were removed. The mother liquor was concentrated under reduced pressure, and the residue was purified with a basic silica gel column chromatography (hexane/ethyl acetate, 5:1 followed by 3:1) to give the title compound (7.33 g, yield 49%). Amorphous. 1H NMR (CDCl3) delta 1.24 (6H, s), 1.33 (6H, s), 1.46 (3H, t, J = 7.0 Hz), 2.36 (2H, s), 2.66 (2H, s), 3.89 (3H, s), 4.18 (2H, q, J = 7.0 Hz), 5.76 (2H, s), 6.59 (1H, s), 6.62 (1H, dd, J = 7.8, 1.5 Hz), 6.73 (1H, d, J = 1.5 Hz), 7.85 (1H, d, J = 7.8 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-cyanobenzoate, other downstream synthetic routes, hurry up and to see.

Reference of 107-91-5, A common heterocyclic compound, 107-91-5, name is 2-Cyanoacetamide, molecular formula is C3H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A substituted alkyl methyl ketone or cyclic ketone (1 equiv) and ethyl formate or ethyl acetic(1 equiv) was added dropwise to absolute ether solution of sodium metal (1 equiv) for 1 h whilemaintained below 20 C. After the addition, the reaction was allowed to stir in an ice bath untilthe sodium metal had disappeared. The precipitate was filtered, washed with absolute ether anddried to give the corresponding compound which was directly used for the next step without further purification. To a solution of previous product (1 equiv), and cyanoacetamide (1.05 equiv) in water was stirred6 min at room temperature. The mixture was added dropwise piperidine acetate solution (0.3 equiv),which was prepared from piperidine (1 equiv), acetic acid (1 equiv) and water (5 equiv). The solutionwas heated to reflux for 2 h. Then, the reactor was cooled to room temperature, and adjusted to pH 4 by 4 N hydrochloric acid. The resulting solid was filtered, respectively washed with water and ether,and dried to give the corresponding compound which was purified by recrystallizing using menthol as solvent. 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1a): 58% yield, white solid, m.p. 264-266 C(lit. [24] 294 C), 1H-NMR (DMSO-d6, 600 MHz): delta 12.31 (br, 1H), 6.16 (s, 1H), 2.30 (s, 3H), 2.22 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.