Month: April 2021

Some common heterocyclic compound, 21423-81-4, name is 3-Chloro-4-methylbenzonitrile, molecular formula is C8H6ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6ClN

Example 45 Preparation of 4-(Bromomethyl)-3-chlorobenzonitrile (CHO) To a stirred solution of 3-chloro-4-methylbenzonitrile (5 g, 25.4 mmol) in carbon tetrachloride (CCl4; 50 mL) under an argon atmosphere was added NBS (5.16 g, 29 mmol), and the mixture was degassed for 30 min. To this was added azobisisobutyronitrile (AIBN; 0.3 g, 1.8 mmol), and the resultant reaction mixture was heated at reflux for 4 h. The reaction mixture was cooled to ambient temperature, washed with H2O, and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2, 100-200 mesh; 5% EtOAc in n-Hexane) to afford the title compound as a white solid (4.8 g, 68%): mp 87-88 C.; 1H NMR (400 MHz, CDCl3) delta 7.71 (s, 1H), 7.59 (s, 2H), 4.60 (s, 2H); ESIMS m/z 229.77 ([M+H]+); IR (thin film) 2235, 752, 621 cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21423-81-4, its application will become more common.

Application of 868-54-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Heterocyclic ketene aminals (1 mmol), aryl aldehydes (1.2 mmol), malononitriledimer (1.5 mmol), acetic acid (1 mmol), piperidine (1 mmol) and ethanol (10 mL)were stirred at refluxing for 1 h. After completion of the reaction (confirmed by TLC),the reaction mixture was filtered to afford the crude product, which was furtherwashed with 95% ethanol to give pure product 4.

The synthetic route of 2-Aminoprop-1-ene-1,1,3-tricarbonitrile has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 151-18-8, name is 3-Aminopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 151-18-8, HPLC of Formula: C3H6N2

Intermediate 28-2 : N-(2-C yanoethyl)-2-(q r,4s)-5 ‘-(4,4,5,5-tetramethyl- 1 ,3,2- dioxaborolan-2-yl)-2′,3′-dihydrospiro[cvclohexane-l,l’-indenel-4-yl)acetamide3-Aminopropionitrile (0.215 mL, 2.94 mmol) was added to a stirred solution of Intermediate 28-3 (725 mg, 1.96 mmol), N-ethyldiisopropylamine (1.023 mL, 5.87 mmol) and PyBROP (1.369 g, 2.94 mmol) in DCM (50 mL). The resulting solution was stirred at ambient temperature for 4 hours. The reaction mixture was evaporated to dryness and redissolved in EtOAc (125 mL), and washed sequentially with 2M HCl (75 mL) and saturated brine (75 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 0 to 100% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford the title compound (900 mg, 109 %) as a white foam.1H NMR (400 MHz, DMSO) delta 1.09 – 1.20 (2H, m), 1.27 (12H, s), 1.42 – 1.46 (2H, m), 1.53 – 1.67 (4H, m), 1.72 – 1.79 (IH, m), 1.90 (2H, t), 2.03 (2H, d), 2.63 (2H, t), 2.81 (2H, t), 3.26 – 3.29 (2H, m), 7.17 (IH, d), 7.46 (IH, d), 7.48 (IH, s), 8.16 (IH, t); m/z 423 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1187-42-4, name is Diaminomaleonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H4N4

General procedure: To a mixture of 2,3-diaminomaleonitrile (1 mmol) and corresponding aromatic aldehyde (1 mmol) in H2O (5 mL), cerium (IV) ammonium nitrate (5 molpercent) was added and the reaction mixture stirred at room temperature for the desired time, as shown in Table 3. After completion of the reaction (reaction progress was monitored by TLC, ethyl acetate/n-hexane, 3:1), cold water (5?10 mL) was addedand the solid was filtered and washed with cold water/ethanol and air-dried to give the Schiff base product.

The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.

Electric Literature of 85068-32-2, These common heterocyclic compound, 85068-32-2, name is 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Acetonitrile Aryl (253 mg, 1.0 mmol) was dissolved in THF (5 mL) sodium hydride was added slowly (60% in oil, 50 mg, 1.3 mmol) to 0 C, was stirred at room temperature for 1 hour. Tetrakis (triphenylphosphine) palladium (58 mg, 0.05 mmol), 1,1′-bis (diphenylphosphino) ferrocene (55 mg, 0.1 mmol), 5,10-dibromonaphtho [1,2-b: 5,6-b ‘] added dithiophene (200 mg, 0.5 mmol) and the resulting mixture was stirred under heating for 10 hours. After the reaction was completed, it cooled to room temperature to give put water (10 mL) and HCl (1 M, 3 mL) was stirred for 1 hour. The resulting solid product was filtered and then washed with water and methanol. Was added to acetonitrile (10mL) added to the obtained solid to give an aqueous solution of bromine (2 mL) was stirred for 30 minutes. Again filtered and washed with acetonitrile, ethanol, hexane. Next, wash with hot chlorobenzene to give a solid state, compound 5 of reddish black. (0.28 Mg, 75% yield)

Statistics shows that 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 85068-32-2.

These common heterocyclic compound, 1194-02-1, name is 4-Fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H4FN

General procedure: General Procedure for Preparation of Tetrazoles in Water(Method II). TBAHS (0.25 mmol) was added to a mixture of nitrile (1 mmol), sodium azide (1.5 mmol), and 2 mL H2O in around-bottomed flask. The reaction mixture was heated to 85 C. After completion of the reaction (as monitored by TLC), the crude reaction mixture was transferred into a separatory funnel, to which was added 1 N HCl (15 mL) extracted by ethylacetate (EtOAc, 10 mL × 5). The combined organic layers were washed with H2O and dried over anhydrous sodium sulfate, and were evaporated under reduced pressure to give pure 5-substituted-1H-tetrazole.

The synthetic route of 4-Fluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 13388-75-5, The chemical industry reduces the impact on the environment during synthesis 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, I believe this compound will play a more active role in future production and life.

2-(3,5-dimethoxyphenyl)acetonitrile (100 g, 564 mmol, Eq: 1.00) was disolved in THF (500 mL). The solution was cooled to 0C and iodomethane (324 g, 142 mL, 2.26 mol, Eq: 4.0) was added. 1 M Potassium tert-butoxide solution in THF (1.69 L, 1.69 mol, Eq: 3) was added dropwise at 0C-2C over 60 min (conversion > 99% by GC after end addition). After 1 h at 0C, the reaction mixture was added to a stirred mixture of MTBE (1.5 L) and water (750 mL). The organic phase was separated, washed twice with 25% aqueous NaCl (750 mL), dried over Na2S04, filtered and concentrated under reduced pressure to give 115.8 g of the title compound as an oil (98.5a% by GC).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3,5-Dimethoxyphenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Related Products of 61150-58-1,Some common heterocyclic compound, 61150-58-1, name is 2-(2-Bromo-4-fluorophenyl)acetonitrile, molecular formula is C8H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add sodium hydride (1 g, 42.1 mmol) to a stirred solution of (2-bromo-4- fluoro-phenyl)-acetonitrile (3 g, 14 mmol) in 10 mL of dimethyl formamide (DMF) at 0 0C. Stir the mixture at 0 0C to RT for half an hour. Add methyl iodide (6 g, 42 mmol). Stir for another 30 min. Quench the reaction with water. Extract the product into DCM. Dry the organic phase over sodium sulfate and concentrate to give an oily residue. Purify the residue by flash column chromatography (FCC) (hexane to 20 % ethyl acetate in hexane as gradient elute) to give the title compound as a white solid (2.2 g, 65 %). 1H NMR (400 MHz, CDCl3) delta 7.41-7.47 (m, 2H), 7.03-7.08 (m, IH), 1.88 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Bromo-4-fluorophenyl)acetonitrile, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83101-12-6, name is 4-(3-Hydroxypropyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H11NO

Example 5: Preparation of further compounds according to the invention.Amidine compounds 8 were synthesised as described by Powers et al. (scheme 2), but we used the procedure with Cu(OTf)2 to prepare the diphenyl phosphonate (20) (Jackson, S. D.; Fraser, S. A.; Ni, L.-M. ; Kam, C-M . ; Winkler, U. ; Johnson, D. A.; Froelich, C. J.; Hudig, D.; and Powers, J. C. Synthesis and Evaluation of Diphenyl Phosphonate Esters as Inhibitors of the Trypsin-like Granzymes A and K and Mast Cell Tryptase. J. Med. Chem., 1998, 41 , 2289-2301). Z-(4-AmPhGly)p(OPh)2 was prepared by a Lewis acid catalyzed amidoalkylation reaction, starting with cyanobenzaldehyde (18a) to give Z-(4- CN-PhGly)p(OPh)2 (20a) which was converted to the amidine (8a) using a Pinner type reaction. The 4-amidinophenylalanine phosphonate diphenyl ester derivative Z-(4- AmPhe)p(OPh)2 was synthesised in the same way from 4-cyanophenylacetaldehyde. 4- EPO Cyanophenylacetaldehyde (18b) was made from 4-cyanobenzaldehyde using a Darzen condensation (scheme 3). 4-(3-Oxo-propyl)-benzonitrile (18c) was synthesised from cyanobenzaldehyde: a Wittig olefination between 4-cyanobenzaldehyde and triphenylphosphoranylidene acetic acid ethyl ester followed by a reduction with NaBH4 afforded 3-(4-cyanophenylpropanol) (21) (Baraldi, G. P.; Cacciari, B.; Romagnoli, R.; Spalluto, G.; Monopoli, A.; Ongini, E. ; Varani, K. and Borea, P. A. 7-Substituted 5-Amino- 2-(2-furyl)pyrazolo[4,3-e]-1 ,2,4-triazolo[1 ,5-c]pyrimidines as A2A Adenosine Receptor Antagonists: A study on the Importance of Modifications at The Side Chain on the Activity and Solubility. J. Med. Chem., 2002, 45, 115-126). This alcohol is oxidised with the Dess Martin reagent to aldehyde 18c.Diphenyl 1-(lambda/-benzyloxycarbonylamino)-1-(4-cyanophenyl)propanephosphonate (20c)3-(4-cyanophenyl)propanol was oxidised with the dess-martin reagent to the aldehyde.The crude product was immediately dissolved in DCM without any further purification. The modified birum Oleksyszin reaction was used to prepare the diphenyl phosphonate. The obtained product was purified with flashchromatography.21percent yield starting from 3-(4-cyanophenyl)propanol1H NMR (CDCI3, 400 MHz); delta 2.1 (m, 1H), 2.35 (m, 1 H), 2.8 (m, 1 H), 2.9 (m, 1H), 4.5 (m,1H), 5.1 (m, 2H), 5.7 (d, 1 H), 7.1-7.4 (m, 16H), 7.5 (m, 3H) MS (ESI) : m/z M+1 = 527

The synthetic route of 83101-12-6 has been constantly updated, and we look forward to future research findings.

Application of 41171-91-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41171-91-9 name is 3-Oxocyclopentanecarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 34 N-3-cyanocyclopentyl-4-(2-(3-amino-phenoxy)ethyl)morpholine 4-(2-(3-aminophenoxy)ethyl)morpholine (2.15 g, 9.67 mmol) and 3-cyanocyclopentanone (1.06 g, 9.67 mmol) (prepared according to the process described by Della, E.; Knill, A.; Aust. J. Chem.; 47; 10; 1994; 1833-1842) were combined in 1% AcOH /MeOH (50 ml). To this solution was added NaBH3CN (925 mg, 14.5 mmol) in portions. After 12 h, the solvent was evaporated off and the residue partitioned between saturated NaHCO3 and ethyl acetate. The aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over MgSO4 and evaporated down. The title compound was purified by flash chromatography with ethyl acetate as the eluent, 2.1 g MS (MH+) 316.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Oxocyclopentanecarbonitrile, and friends who are interested can also refer to it.