Related Products of 61150-58-1,Some common heterocyclic compound, 61150-58-1, name is 2-(2-Bromo-4-fluorophenyl)acetonitrile, molecular formula is C8H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add sodium hydride (1 g, 42.1 mmol) to a stirred solution of (2-bromo-4- fluoro-phenyl)-acetonitrile (3 g, 14 mmol) in 10 mL of dimethyl formamide (DMF) at 0 0C. Stir the mixture at 0 0C to RT for half an hour. Add methyl iodide (6 g, 42 mmol). Stir for another 30 min. Quench the reaction with water. Extract the product into DCM. Dry the organic phase over sodium sulfate and concentrate to give an oily residue. Purify the residue by flash column chromatography (FCC) (hexane to 20 % ethyl acetate in hexane as gradient elute) to give the title compound as a white solid (2.2 g, 65 %). 1H NMR (400 MHz, CDCl3) delta 7.41-7.47 (m, 2H), 7.03-7.08 (m, IH), 1.88 (s, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Bromo-4-fluorophenyl)acetonitrile, its application will become more common.