Electric Literature of 85068-32-2, These common heterocyclic compound, 85068-32-2, name is 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Acetonitrile Aryl (253 mg, 1.0 mmol) was dissolved in THF (5 mL) sodium hydride was added slowly (60% in oil, 50 mg, 1.3 mmol) to 0 C, was stirred at room temperature for 1 hour. Tetrakis (triphenylphosphine) palladium (58 mg, 0.05 mmol), 1,1′-bis (diphenylphosphino) ferrocene (55 mg, 0.1 mmol), 5,10-dibromonaphtho [1,2-b: 5,6-b ‘] added dithiophene (200 mg, 0.5 mmol) and the resulting mixture was stirred under heating for 10 hours. After the reaction was completed, it cooled to room temperature to give put water (10 mL) and HCl (1 M, 3 mL) was stirred for 1 hour. The resulting solid product was filtered and then washed with water and methanol. Was added to acetonitrile (10mL) added to the obtained solid to give an aqueous solution of bromine (2 mL) was stirred for 30 minutes. Again filtered and washed with acetonitrile, ethanol, hexane. Next, wash with hot chlorobenzene to give a solid state, compound 5 of reddish black. (0.28 Mg, 75% yield)
Statistics shows that 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 85068-32-2.