Application of 41171-91-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41171-91-9 name is 3-Oxocyclopentanecarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 34 N-3-cyanocyclopentyl-4-(2-(3-amino-phenoxy)ethyl)morpholine 4-(2-(3-aminophenoxy)ethyl)morpholine (2.15 g, 9.67 mmol) and 3-cyanocyclopentanone (1.06 g, 9.67 mmol) (prepared according to the process described by Della, E.; Knill, A.; Aust. J. Chem.; 47; 10; 1994; 1833-1842) were combined in 1% AcOH /MeOH (50 ml). To this solution was added NaBH3CN (925 mg, 14.5 mmol) in portions. After 12 h, the solvent was evaporated off and the residue partitioned between saturated NaHCO3 and ethyl acetate. The aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over MgSO4 and evaporated down. The title compound was purified by flash chromatography with ethyl acetate as the eluent, 2.1 g MS (MH+) 316.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Oxocyclopentanecarbonitrile, and friends who are interested can also refer to it.