Synthetic Route of 52798-01-3, These common heterocyclic compound, 52798-01-3, name is Methyl (4-cyanophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Concentrated hydrochloric acid (37%, 259 mg) was added dropwise to a mixture of methyl 2- (4-cyanophenyl) acetate (3.2 g, 18.3 mmol) and10% palladium on carbon catalyst (175 mg) in 50 ml of methanol.Hydrogen gas was bubbled in and stirred for 12 hours at room temperature.Excess catalyst was removed by filtration and the organic phase was distilled off under reduced pressure.The filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (50 mL), washed with brine, dried and concentrated. The residue was purified by column chromatography (methylene chloride / methanol = 20/1) to give the title compound 2.29 g (70%).
Statistics shows that Methyl (4-cyanophenyl)acetate is playing an increasingly important role. we look forward to future research findings about 52798-01-3.