Adding a certain compound to certain chemical reactions, such as: 151-18-8, name is 3-Aminopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 151-18-8, HPLC of Formula: C3H6N2
Intermediate 28-2 : N-(2-C yanoethyl)-2-(q r,4s)-5 ‘-(4,4,5,5-tetramethyl- 1 ,3,2- dioxaborolan-2-yl)-2′,3′-dihydrospiro[cvclohexane-l,l’-indenel-4-yl)acetamide3-Aminopropionitrile (0.215 mL, 2.94 mmol) was added to a stirred solution of Intermediate 28-3 (725 mg, 1.96 mmol), N-ethyldiisopropylamine (1.023 mL, 5.87 mmol) and PyBROP (1.369 g, 2.94 mmol) in DCM (50 mL). The resulting solution was stirred at ambient temperature for 4 hours. The reaction mixture was evaporated to dryness and redissolved in EtOAc (125 mL), and washed sequentially with 2M HCl (75 mL) and saturated brine (75 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 0 to 100% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford the title compound (900 mg, 109 %) as a white foam.1H NMR (400 MHz, DMSO) delta 1.09 – 1.20 (2H, m), 1.27 (12H, s), 1.42 – 1.46 (2H, m), 1.53 – 1.67 (4H, m), 1.72 – 1.79 (IH, m), 1.90 (2H, t), 2.03 (2H, d), 2.63 (2H, t), 2.81 (2H, t), 3.26 – 3.29 (2H, m), 7.17 (IH, d), 7.46 (IH, d), 7.48 (IH, s), 8.16 (IH, t); m/z 423 (M+H)+.
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